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Your Baby

“Revolutionary” Newborn Has 3 Parents

1:45

There’s been a first in the use of in vitro fertilization (IVF) to help parents avoid passing on a fatal rare disease to their baby.

In what many medical experts are calling a “revolutionary” medical event, a baby with DNA from three donors has been born.

As first reported in New Scientist, a science and technology magazine published in the U.K., the baby boy was born on April 6, 2016 and doctors say he appears healthy. His parents were treated by U.S. fertility specialists in Mexico, where there are no laws prohibiting such methods. His mother carries a genetic mutation for Leigh syndrome, a rare neurological disorder that usually becomes apparent in the first year of life and is generally fatal.

The newborn’s mother had suffered four miscarriages and had two children who died from Leigh syndrome, one at age six and one at eight months. It’s a devastating disease for parents and children. Symptoms of Leigh disease usually progress rapidly and lead to generalized weakness, a lack of muscle tone and a buildup of lactic acid in the body, which can cause respiratory and kidney problems. Children rarely live more than six or seven years.

While the mother herself is healthy, a gene for the disease resides in her DNA, in the mitochondria that powers cells. In this mother’s case, about 25 percent of her mitochondria reportedly carries the disease-causing mutation.

In order to avoid transferring the disease, the couple sought help from Dr. John Zhang, a reproductive endocrinologist at New Hope Fertility Center in New York City. 

“This mitochondrial disease is usually a very devastating situation for the babies and the family,” Zhang told CBS News.

The controversial procedure involved using the three-parent IVF technique to ensure that the disease mutation would not be passed along to the baby. So far, it seems to have worked.

The procedure, called spindle nuclear transfer, involves removing the healthy nucleus from one of the mother’s eggs and transferring it to a donor-egg, which had, had its nucleus removed. The resulting egg – with nuclear DNA from the mother and mitochondrial DNA from a donor – was then fertilized with the father’s sperm. 

The resulting embryo contained genetic material from three parents – the mother, the egg donor, and the father.

According to New Scientist, the scientists in this case created five embryos using the technique. Only one developed normally and that embryo was implanted in the mother.

The baby has not shown any signs of developing the illness, Zhang said. His mitochondria have been tested and less than one percent carries the mutation, believed to be too low a level to lead to disease.

The controversial fertility method is not legal in the United States. Zhang told New Scientist that they conducted the procedure in Mexico because “there are no rules” there.

The procedure received widespread media attention when lawmakers in the U.K. became the first to approve its use last year.

Sian Harding, a medical professor and bioethics adviser who reviewed the ethics of the technique in the U.K., told New Scientist the case seems to have been handled according to ethical standards.

“It’s as good as or better than what we’ll do in the U.K.,” said Harding.

Much of the controversy surrounding this procedure involves safety and religious concerns.

Harding notes that this is not the first time multiple DNA has been used to try and create a healthy baby. “Last time embryologists tried to create a baby using DNA from three people was in the 1990s, when they injected mitochondrial DNA from a donor into another woman’s egg, along with sperm from her partner. Some of the babies went on to develop genetic disorders, and the technique was banned. The problem may have arisen from the babies having mitochondria from two sources.”

In Britain, where the procedure allowing DNA from three parents was approved in February 2015, leaders disagreed heatedly on the issue while it was up for debate in the House of Commons, with some raising concerns about “designer babies” and “playing God.” Leading churches in Britain – both Protestant and Catholic – opposed the procedure on religious and ethical grounds.

Medical and moral concerns about this IVF method are most likely going to continue as experts look for ways to refine the controversial procedure.

But for one couple, being able to cradle their newborn - that shows no sign of carrying the deadly Leigh disease - will forever be a precious gift. 

Story source: Mary Brophy Marcus, http://www.cbsnews.com/news/first-3-parent-dna-baby-born-rare-disease/

 

Your Baby

FDA Recommends Limits on Arsenic in Rice Baby Food

1:45

The Food and Drug Administration (FDA) on Friday proposed new limits for inorganic arsenic in infant rice cereal, an effort to reduce the leading source of arsenic exposure for babies.

The draft guidance to industry would cap the inorganic arsenic at 100 parts per billion, a level that most infant rice cereals already meet, or are close to meeting, the agency said.

Arsenic is naturally present in water, air, food and soil in two forms: organic and inorganic. Organic arsenic passes through the body quickly and is less toxic. But inorganic arsenic may pose a cancer risk if consumed at high levels or over a long period of time. Rice is thought to have arsenic in higher levels than most other foods because it is grown in water on the ground, optimal conditions for the contaminant to be absorbed.

Babies' consumption of rice, which is primarily through rice cereal, is about three times greater than that of adults, according to the FDA. Most people consume the highest amount of rice, relative to their weights, at about 8 months of age.

The proposed limit is based on testing of rice and non-rice products, as well as a 2016 FDA risk assessment on the association between exposure to inorganic arsenic and adverse pregnancy outcomes and neurological effects in early life.

The agency said that inorganic arsenic exposure can result in a child's decreased performance on certain developmental tests.

The agency tested 76 samples of infant rice cereal from retail stores and found that nearly half met the agency's proposed limit of 100 parts per billion of inorganic arsenic. More than three-quarters of the samples had levels at or below 110 parts per billion.

The agency advised parents to feed their babies iron-fortified cereals; they can include oat, barley and other grains. It also urged pregnant women to consume a variety of foods, including grains, such as wheat, oats and barley. The FDA also noted that cooking rice in excess water - six to 10 parts water to one part rice - can reduce a significant part of the inorganic arsenic.

Urvashi Rangan, executive director of the Consumer Reports Food Safety & Sustainability Center, said that Consumer Reports was pleased by the FDA's proposal, which he said was close to the level proposed by the group three years ago. But he said the organization remains concerned that other rice-based products consumed by children and adults don't have any such standards. "This is particularly true of children's ready-to-eat cereals," he said, urging the FDA to set levels for these other products.

The agency will accept public comments on the proposed limits for 90 days.

Story source: Laurie McGinley, http://www.chicagotribune.com/lifestyles/health/ct-infant-rice-cereal-inorganic-arsenic-20160402-story.html

 

Your Baby

Spit-Cleaning Your Infant’s Binky

1.45 to read

Have you ever sucked on your baby’s pacifier to clean it? Many parents have. Babies drop their binkies all the time and if you’re in a hurry or just figure a little spit-cleaning won’t hurt, you’re more likely to stick it in your own mouth and give it a quick once over.

A new study out of Sweden says the spit-cleaning technique may actually help your infant avoid eczema and asthma.

“It was surprising that the effect was so strong,” says pediatric allergist Dr. Bill Hesselmar of Queen Silvia Children’s Hospital in Gothenburg, Sweden, lead author of the study published Monday in the journal Pediatrics.

The study involved 136 infants who used a pacifier in their first 6 months. 65 of the infants had parents that reported sucking the pacifier to clean it. In those children, both eczema and asthma were strongly reduced when they were examined at 18 months of age. At 36 months of age, the protective effect remained for eczema but not for asthma.

Scientists didn’t know why the sucking on the baby’s pacifier acted as a protector or whether it was filtering out germs. The technique didn’t have any impact on respiratory illness, meaning that the babies were not more likely to get a cold or the flu from their parents. Common sense would dictate that if you have a cold or the flu or any other contagious condition, then it’s not a good idea to suck on your baby’s binky. Otherwise, maybe it’s not such a bad idea.

Why is sucking on your infant’s pacifier possibly helpful in preventing asthma or eczema in your child? Scientists hypothesize that tiny organisms in the saliva of the parents may be why. Parent’s saliva introduces gut micoflora that live in the digestive tract of the baby. “We know that if infants have diverse microflora in the gut, then children will have less allergy and less eczema,” says Hesselmar. “When parents suck on the pacifier, they are transferring microflora to the child.”

Many pediatricians and family doctors are concerned that children are being “excessively cleaned” into illness. With anti-bacterial soaps and swipes being used on everything, and kids not allowed to get dirty, their immune system isn’t getting the workout it needs to help fight off common illnesses. The bacterial microorganisms provided in the parent’s saliva might help stimulate the baby’s immune system.

“The most exciting result was the eczema,” says Christine Johnson, chair of the public health department at Detroit’s Henry Ford Hospital. “I’m a bit more skeptical about the asthma findings because asthma is hard to measure before a child is five or six years old.”

Hesselmar also urges moms to lick the baby’s pacifier if their child was delivered by C-section. Vaginal delivered babies receive quite a bit of microbes during delivery. C-section babies can be more prone to allergies. “If they are using a pacifier and those parents think it’s OK to suck on the pacifier, then yes, I would recommend it,” Hesselmar says.

Some parents may find the idea of picking up a pacifier that’s fallen on the floor and putting it in their mouth kind of disgusting. That’s fine, there’s no need to worry about it. If the idea doesn’t bother you, all the better says Hesselmar, “I haven’t heard of anyone getting ill from it,” he says. “There isn’t much bacteria on the floor.”

Source: Barbara Mantel, http://www.today.com/moms/why-it-may-be-ok-spit-clean-your-babys-binkie-6C9773378

Your Baby

Starting Baby on Solid Foods

Your goal over the next few months is to introduce a wide variety of foods. If your baby doesn't seem to like a particular food, reintroduce it at later meals. It can take quite a few tries before kids warm up to certain foods.Starting baby on solid foods can be an exciting and perplexing time for parents. What foods should I start with? How much? How often?

The American Academy of Pediatrics currently recommends gradually introducing solid foods when a baby is about 6 months old. Your pediatrician, however, may recommend starting as early as 4 months depending on your baby's readiness and nutritional needs. Be sure to check with your pediatrician before starting any solid foods. Is your baby ready? Breast milk or formula is the only food your newborn needs. Within four to six months, however, your baby will begin to develop the coordination to move solid food from the front of the mouth to the back for swallowing. At the same time, your baby's head control will improve and he or she will learn to sit with support — essential skills for eating solid foods. If you're not sure whether your baby is ready, ask yourself these questions: •       Can your baby hold his or her head in a steady, upright position? •       Can your baby sit with support? •       Is your baby interested in what you're eating? If you answer yes to these questions and you have the OK from your baby's doctor or dietitian, you can begin supplementing your baby's liquid diet. What Foods to Start With. Continue feeding your baby breast milk or formula as usual. Then: •       Start with baby cereal. Mix 1 tablespoon (15 milliliters) of a single-grain, iron-fortified baby cereal with 4 to 5 tablespoons (60 to 75 milliliters) of breast milk or formula. Many parents start with rice cereal. Even if the cereal barely thickens the liquid, resist the temptation to serve it from a bottle. Instead, help your baby sit upright and offer the cereal with a small spoon once or twice a day. Once your baby gets the hang of swallowing runny cereal, mix it with less liquid. For variety, you might offer single-grain oatmeal or barley cereals. Your baby may take a little while to "learn" how to eat solids. During these months you'll still be providing the usual feedings of breast milk or formula, so don't be concerned if your baby refuses certain foods at first or doesn't seem interested. It may just take some time. Do not add cereal to your baby's bottle unless your doctor instructs you to do so, as this can cause babies to become overweight and doesn't help the baby learn how to eat solid foods •       Add pureed meat, vegetables and fruits. Once your baby masters cereal, gradually introduce pureed meat, vegetables and fruits. Offer single-ingredient foods at first, and wait three to five days between each new food. If your baby has a reaction to a particular food — such as diarrhea, a rash or vomiting — you'll know the culprit. •       Offer finely chopped finger foods. By ages 8 months to 10 months, most babies can handle small portions of finely chopped finger foods, such as soft fruits, well-cooked pasta, cheese, graham crackers and ground meat. As your baby approaches his or her first birthday, mashed or chopped versions of whatever the rest of the family is eating will become your baby's main fare. Continue to offer breast milk or formula with and between meals. Foods to Avoid for Now. Some foods are generally withheld until later. Do not give eggs, cow's milk, citrus fruits and juices, and honey until after a baby's first birthday. Eggs (especially the whites) may cause an allergic reaction, especially if given too early. Citrus is highly acidic and can cause painful diaper rashes for a baby. Honey may contain certain spores that, while harmless to adults, can cause botulism in babies. Regular cow's milk does not have the nutrition that infants need. Fish and seafood, peanuts and peanut butter, and tree nuts are also considered allergenic for infants, and shouldn't be given until after the child is 2 or 3 years old, depending on whether the child is at higher risk for developing food allergies. A child is at higher risk for food allergies if one or more close family members have allergies or allergy-related conditions, like food allergies, eczema, or asthma. Introducing Juice. Juice can be given after 6 months of age, which is also a good age to introduce your baby to a cup. Buy one with large handles and a lid (a "sippy cup"), and teach your baby how to maneuver and drink from it. You might need to try a few different cups to find one that works for your child. Use water at first to avoid messy clean-ups. Serve only 100% fruit juice, not juice drinks or powdered drink mixes. Do not give juice in a bottle and remember to limit the amount of juice your baby drinks to less than 4 total ounces (120 ml) a day. Too much juice adds extra calories without the nutrition of breast milk or formula. Drinking too much juice can contribute to obesity can cause diarrhea. Infants usually like fruits and sweeter vegetables, such as carrots and sweet potatoes, but don't neglect other vegetables. Your goal over the next few months is to introduce a wide variety of foods. If your baby doesn't seem to like a particular food, reintroduce it at later meals. It can take quite a few tries before kids warm up to certain foods.

Your Baby

Acetaminophen Ranks Highest in Infants’ Accidental Poisonings

2:00

Infants are just as susceptible to accidental poisonings as toddlers and older children, according to a new study. Acetaminophen (such as Tylenol) was the most common medication error for infants. Some of the other products associated with accidental poisonings may surprise you.

The researchers look at data from all poison control center calls in a national database from 2004 to 2013 that related to babies younger than 6 months old.

Acetaminophen was the most reported medication mistake followed by H2-blockers (for acid reflux), gastrointestinal medications, combination cough / cold products, antibiotics and ibuprofen (such as Motrin or Advil).

The most common non-medication exposures were diaper care and rash products, plants and creams, lotions and make-up, the investigators found.

"I was surprised with the large number of exposures even in this young age group," said lead author Dr. A. Min Kang, a medical toxicology fellow at Banner-University Medical Center Phoenix in Arizona.

"Pediatricians typically do not begin poison prevention education until about 6 months of age, since the traditional hazard we think about is the exploratory ingestion -- that is when kids begin to explore their environment and get into things they are not supposed to," Kang added.

The research team found that there were more than 270,000 exposures reported during the decade of data, 97 percent of which were unintentional. However, over 37 percent were related to medication mistakes.

Acetaminophen was involved in more than 22,000 medication exposures and nearly 5,000 general exposures. This high rate reflects its frequent use because it's recommended instead of ibuprofen for infants, Kang pointed out.

"The concern with too much acetaminophen is liver failure although, luckily, young children are considered to be somewhat less likely to experience this than an adult because the metabolism is a little different," Kang said.

The current rate of acetaminophen mistakes may actually be lower notes Dr. Michael Cater, a pediatrician with St. Joseph Hospital in Orange, California, because infant drops are now standardized across manufacturers.

The number of ibuprofen exposures, however, surprised Cater since ibuprofen isn't recommended for those under 6 months old.

"Also surprising was the number of ethanol poisonings," likely from parents leaving empty glasses or bottles of alcohol around, he said. "Low-lying plants, some of which are toxic, are a source of concern, and this was a bit of a surprise to me."

Diaper creams and lotions likely top the list because they're easily reachable by infants when left on the diaper-changing areas, Cater added.

The AAP has a policy statement recommending that all liquid medications use metric units for dosing and that they include administration devices, such as syringes, to reduce the chance of an overdose.

Perhaps doctors should offer poison prevention education to caregivers earlier, even starting when a baby leaves the hospital, Kang suggested.

The poison control hotline phone number- 1-800-222-1222 – should also be posted in the home and programmed into parents and caregiver’s cell phones Kang said.

The findings were published online in the January edition of the journal Pediatrics, and in the February print edition.

Source: Tara Haelle, http://www.webmd.com/children/news/20160113/acetaminophen-tops-list-of-accidental-infant-poisonings

Your Baby

Gap Between Pregnancies Linked to Autism

2:00

Does it make a difference how long a woman waits between pregnancies in the health of her newborn?  According to a new large study, the closer the pregnancies, the higher the risk that her child will have autism or other neurodevelopmental disabilities.

"Based on the current best available evidence, it appears that the ideal inter-pregnancy interval -- the time elapsed between the birth of the immediate older sibling and the conception of the younger sibling -- is 2 to 5 years, in order to reduce the risk of autism," said study author Dr. Agustin Conde-Agudelo. He is a researcher at the World Health Organization Collaborating Center in Human Reproduction at the University of Valle in Cali, Colombia.

Researchers looked at existing studies involving more than 1.1 million children and also found that waiting too long between pregnancies (5 years or more) could raise the odds of autism.

The reasons for the link between short pregnancy spacing and autism are not known noted Conde-Agudelo. He said that scientists believe nutrition and other factors may play a role.

The study doesn’t prove that either long or short intervals between pregnancies actually causes autism, just that there seems to be an association between the two.

Conde-Agudelo and his team reviewed seven large studies reporting a link between short birth spacing and autism. The investigators found that children born to women with less than 12 months between pregnancies were nearly twice as likely to develop autism as children born to women with three years or longer between pregnancies.

Three of those studies also reported a significant link between long pregnancy spacing and autism, especially for two milder types, which were formerly called Asperger's syndrome and pervasive developmental disorder.

Meanwhile, the findings also suggested that shorter pregnancy spacing was associated with an increased risk of developmental delays and cerebral palsy, which can affect body movement, muscle coordination and balance.

Conde-Agudelo and other researchers conjectured that the mother’s depleted levels of folic acid between closely spaced pregnancies might play a role in the rise of autism risk.

The B vitamin folic acid is necessary for proper brain and spinal cord development in fetuses, and women are typically advised to take folic acid supplements during pregnancy.

As for longer pregnancy intervals also potentially linked to autism, Conde-Agudelo said it's been hypothesized that related factors such as infertility, unintended pregnancy and maternal inflammation levels may affect autism possibility.

Most neurodevelopmental disabilities, including autism, are thought to be caused by a complex mix of factors. These include genetics, environment, parental health and behaviors during pregnancy, and complications during birth, the researchers said in background notes.

The study was published in the April online edition of the journal Pediatrics, and will appear in the May print issue.

Story source: Maureen Salamon,  http://consumer.healthday.com/cognitive-health-information-26/autism-news-51/pregnancies-close-together-may-raise-autism-risk-study-says-709733.html

Your Baby

No Link Between Vaccines and Autism

1.30 to read

A new study slated to appear in the Journal of Pediatrics, says that there is no association between the amount of vaccines a young child receives and autism. Some parents have worried that there may be a link and have opted out of having their child vaccinated or reduced the number of vaccines recommended.

The percentage of children diagnosed with autism spectrum disorder (ASD) has increased by 72% since 2007. Some experts believe that changes in the diagnostic criteria may account for some of the increase as well as better screening tools and rating scales.

According to a statement released from the journal, researchers from the Centers for Disease Control and Prevention and Abt Associates analyzed data from children with and without ASD.

Researchers examined each child's cumulative exposure to antigens, the substances in vaccines that cause the body's immune system to produce antibodies to fight disease, and the maximum number of antigens each child received in a single day of vaccination, the journal's statement said.

The antigen totals were the same for children with and without ASD, researchers found.

Scientists believe genetics play a fundamental role in the risk for a child developing autism (80-90%), but recent studies also suggests that the father’s age at the time of conception may also be a contributor by increasing risks for genetic mistakes in the sperm that could be passed along to offspring.

Parents have worried about a link between vaccines and autism for decades despite the growing body of scientific evidence disproving such an association.

Source: Luciana Lopez, http://www.reuters.com/article/2013/03/29/us-usa-health-autism-idUSBRE92S0GO20130329

Your Baby

Recall: Tommee Tippee Electric Bottle and Food Warmers Due to Fire Hazard

1:30

Mayborn USA is recalling about 255,000 Tommee Tippee electric bottle and food warmers because they could overheat and catch fire, according to the U.S. Consumer Product Safety Commission.

This recall involves Tommee Tippee® Closer to Nature® electric bottle and food warmers, sold separately or as an accessory with the Complete Starter Kit or the All in One Newborn Set. The bottle and food warmer is white with a gray adjustable control dial located next to the on/off light. Tommee Tippee is stamped in gray on the front of the unit. It measures about 5 inches high, 5 ½ inches wide and 5 inches long. Bottle and food warmers included on this recall have “Min” or “0” stamped on the left-hand side of the control dial and have the UL logo and a six alpha-numeric batch code that begins with a number and ends with “GY” stamped on the underside. Consumers should visit www.tommeetippee.us/bottle-warmer to complete the free replacement registration form.

The firm has received six reports of bottle and food warmers overheating, melting, smoking and catching on fire; which resulted in $16,000 in property damage.

Consumers should immediately unplug and stop using the recalled bottle and food warmers and contact Mayborn for free replacement warmers.  

The product was sold at merchandise stores including Baby Depot, Baby Heaven, Bealls Outlet, BuyBuy Baby, CVS, Giant, Ideal Baby and Kids, Kohl’s, Marco Baby, Marshalls, Meijer, Ross Stores, Sam’s Club, Target, TJ Maxx, Toys R Us, Walgreens and Wal-Mart nationwide and online at Amazon.com, Diapers.com, Drugstore.com and Quidsi.com from July 2011 through April 2016 for about $21 for the individual bottle and food warmer and about $120 for the starter kit or newborn set.

Consumers can contact Mayborn online at www.tommeetippee.us and click on the recall button at the bottom of home page or toll-free at 844-340-3420 from 9 a.m. to 5 p.m. ET Monday through Saturday for more information.

This Mayborn recall follows another recent recall from the company. In May 2016, over 3 million Tommee Tippee Sippee Spill-Proof Cups were recalled due to the possibility of mold build-up in the removable, one-piece white valve.

Mayborn USA had received 3,066 reports of mold in the removable, one-piece, opaque valve of the Sippee cups, including 68 reports of children experiencing diarrhea, vomiting or other symptoms associated with drinking from a cup with mold in the valve.

Story sources: https://www.cpsc.gov/en/Recalls/2016/Tommee-Tippee-Electric-Bottle-and-Food-Warmers-Recalled-by-Mayborn-USA/

http://www.cpsc.gov/en/Recalls/2016/Tommee-Tippee-Sippee-Cups-Recalled-by-Mayborn-USA/

Your Baby

Recall: Infant Bathtubs Due to Drowning and Impact Injury

1:30

This recall involves 86,000 Summer Infant Lil’ Luxuries Whirlpool, Bubbling Spa & Shower with fabric slings.

Fabric slings on the recalled infant bathtubs can detach from the tub, posing a risk of impact injury and drowning.

CPSC and Summer Infant have received reports of 91 incidents of the sling detaching, including 11 reports of infants who received a bump to the head.

The infant bathtub is a battery-operated whirlpool bath with motorized jets intended for use with children from birth to 2 years. The product contains a fabric sling on a plastic frame onto which the infant is placed for bathing. The fabric sling on the recalled bathtubs does not have a white plastic attachment clip to hold the headrest area of the fabric sling to the plastic frame.

Recalled bathtubs have item numbers 18840, 18850, 18863, and 18873 and were sold between October 2012 and October 2013 with date codes starting with 1210, 1211, 1212, 1301, 1302, 1303, 1304, 1305, 1306, 1307, and 1308, which stand for the two-digit year followed by the two-digit month, on the fabric sling.

Consumers should immediately stop using the fabric sling in the recalled product and contact Summer Infant for a replacement fabric sling with a white plastic attachment clip. Consumers can contact Summer Infant toll free at 844-612-4254 from 9 a.m. to 5 p.m. ET Monday through Thursday and 9 a.m. to 3 p.m. ET on Friday, or online at www.summerinfant.com and click on “Safety Alerts & Recalls” at the bottom of the page for more information.

The recalled items were sold at Toys R Us/Babies R Us and other juvenile product specialty stores nationwide from October 2012 through October 2013 for about $60. CPSC and Summer Infant warn consumers that these tubs could have been and could continue to be sold on the secondhand market.

 

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